Ppt bullous pemphigoid powerpoint presentation free to. Pdf localized bullous pemphigoid on the site of knee. Puvasol induced bullous pemphigoid in a case of psoriasis. Subepidermal blisters occur between the dermis and the epidermis. Occasionally, the inner lining tissue of the mouth, nasal passages, or conjunctivae of the eyes mucous membrane tissue can be involved. Bp is immunologically characterized by tissuebound and circulating autoantibodies directed against either the bp antigen 180 bp180, or bpag2 or the bp antigen 230 bp230, or bpag1e, or even both, which. It includes a widerange of skin conditions and it could be signs of certain illnesses as well. The vesicular form is less usual than the generalized bullous form, it occurs as a group of tensed, small blisters on the erythematous or urticarial base. In some people, the mouth or genitals are also affected. Mucosal involvement of the gi tract is much less common than in pemphigus vulgaris, 47 although one report described esophageal blisters in 4% of patients with typical bullous pemphigoid. Topical and systemic corticosteroids are used initially. The blister often contains a clear liquid with some blood and are not easily ruptured when poked by the fingers. This means that the bullae are actually subepidermal that is between the outer layer epidermis and next layer of the skin the dermis, so they are less fragile than those of pemphigus vulgaris if you see a patient with bullous pemphigoid, youll see lots of intact, tense bullae, rather than a bunch of ruptured bullae covered with scabs.
Doctors can diagnose bullous pemphigoid by examining skin samples under a microscope and checking for certain antibody deposits. Bullous pemphigoid is a rare autoimmune skin disorder that usually, but not always, affects people who are 60 years old or older. Bullous pemphigoid dermatologic disorders merck manuals. The main presentation of bullous pemphigoid is a large acute or subacute skin blister within the armpit, lower abdomen and thigh.
It is classified as a type ii hypersensitivity reaction, with the formation of antihemidesmosome antibodies. Cleveland, oh bullous pemphigoid is an autoimmune blistering dermatologic disease characterized clinically by tense bullae that may develop on normal or erythematous skin. As with other autoimmune disorders, it is caused when the bodys defenses mistake its own tissues as foreign, and attack the cells. A case report article pdf available in serbian journal of dermatology and venereology 81 november 2016. This skin disorder, bullous pemphigoid, is a rare condition that its frequency of occurrence is unknown to the public in the united states. Bullous pemphigoid bp is the most common autoimmune subepidermal blistering disease in western countries, and typically affects the elderly. Bullous pemphigoid bp is an autoimmune subepidermal bullous dermatosis defined immunologically by the existence of autoantibodies directed against 2 structural proteins found in the hemidesmosomes of the dermalepidermal junction. Bullous pemphigoid bp is the commonest subtype of autoimmune blistering disease aibd, a rare but potentially fatal group of skin diseases. Bullous pemphigoid genetic and rare diseases information. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. Bullous pemphigoid information guide, symptoms, pictures, causes, treatment. Bullous pemphigoid is a subepidermal autoimmune blistering disease.
Bullous pemphigoid an overview sciencedirect topics. Bullous pemphigoid bulus pemfihgoid is a rare skin condition that causes large, fluidfilled blisters. Bullous pemphigoid is a rare autoimmune disease of the elderly, characterized by bullae formation on mucocutaneous surfaces. Aug 10, 2018 bullous pemphigoid is a chronic, inflammatory, subepidermal, blistering disease. Bullous pemphigoid is an acquired autoimmune subepidermal bullous disease in which autoantibodies are directed against components of the basement membrane zone of the skin. Cleveland, oh bullous pemphigoid is an autoimmune blistering dermatologic disease characterized clinically by tense bullae that may develop on normal or erythematous. Bullous pemphigoid is an autoimmune disorder that occurs when the immune system attacks the skin and causes blistering. Bullous pemphigoid may present with several distinct clinical. This disease typically affects the elderly and presents with itch and localized or generalized bullous lesions. Pemphigoid definition of pemphigoid by medical dictionary. He said mucous membrane pemphigoid mmp and cicatricial pemphigoid cp typically affect middleaged and older individuals. Bullous pemphigoid is the most commonly seen autoimmune blistering.
Erythrodermic bullous pemphigoid is a clinical variant of bullous pemphigoid. People develop large, itchy blisters with areas of inflamed skin. A man in his 60s with psoriasis and t2dm presented with pruritus and erythematous tense bullae on the limbs. Bullous pemphigoid bp is a chronic, autoimmune, subepidermal, blistering skin disorder unlike pemphigus where the blistering is intraepidermal. Note that this may not provide an exact translation in all languages. Pemphigoid diseases including bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear iga dermatosis, lichen planus pemphigoides, and antip200 pemphigoid are a subgroup of autoimmune bullous skin diseases characterized by an autoantibody response toward structural components of the hemidesmosome resulting in. Bullous pemphigoid is the most commonly seen autoimmune blistering disease in the. Bullous pemphigoid primary care dermatology society uk. Bullous pemphigoid khandpur s, verma p indian j dermatol. Bullous definition and meaning collins english dictionary.
Oct 17, 2014 autoimmune bullous lesions of skin in brief slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. The most common bullous pemphigoid are the generalized bullous form. Fluid filled bullae arise on the folded areas of the skin. Prescription drugs for treating rheumatoid arthritis or the retention of fluid. Ppt bullous skin disorders bsd powerpoint presentation. It might present with blisters or welts seen on arms, legs, groin, mouth or abdomen. Winner of the standing ovation award for best powerpoint templates from presentations magazine. A prototypical antibodymediated organspecific autoimmune disease article pdf available in journal of investigative dermatology 1294. Bullous pemphigoid skin disorders msd manual consumer version. Later, large tense blisters develop on both erythematous and on normal skin and there may be mucosal involvement with blisters and erosions.
Bullous pemphigoid is an autoimmune pruritic skin disease preferentially in elderly people, that may involve the formation of blisters in the space between the epidermal and dermal skin layers. Bullous pemphigoid is the commonest type of autoimmune blistering disease, with an incidence of 12. Aug 10, 2016 bullous pemphigoid is a skin disorder characterized by large blisters. Bullous pemphigoid pictures, symptoms, causes, treatment. Bullous pemphigoid powerpoint presentation free medical. Bullous pemphigoid is an uncommon blistering disease of the elderly, which often starts with itch and urticated and erythematous lesions. The antigenantibody interaction has been demonstrated.
So, this makes it highly important to make proper diagnosis for the condition and making sure that the person with skin disorder is properly. Bullous pemphigoid bp is not only the most common disorder within the pemphigoid group, but also represents the most frequent autoimmune blistering disease in general. Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. Bullous pemphigoid is a chronic and autoimmune disorder that is characterized by blisters on the skin. Professional version the trusted provider of medical information since 1899. Bullous pemphigoid associated with linagliptin treatment. Bullous pemphigoid is an autoimmune disorder usually seen in elderly patients. Aad 6 1938 o iii i i i ii iii journal of the amemcan academy of dermatology volume 16 number 5 part 1 may 1987 ii iii continuing medical education bullous pemphigoid nell korman, ph. Bullous pemphigoid is a chronic autoimmune skin disorder resulting in generalized, pruritic, bullous lesions in elderly patients. Bullous pemphigoid develops when the bodys system of immunity starts an attack on the thinlayer. Like adult bullous pemphigoid, childhood bullous pemphigoid occurs when cells of the bodys immune system produce proteins autoantibodies which attack and damage specific proteins of the basement membrane zone known as bp180 and bp230.
Bullous pemphigoid is an uncommon skin disease characterized by tense blisters on the surface of the skin. Bullous pemphigoid symptoms and causes mayo clinic. Authoritative facts about the skin from dermnet new zealand. Introduction to bullous diseases dermatologic disorders. All specialties including cardiology, dermatology, ophthalmology, dentistry, hepatology, nephrology, neurology powerpoints and templates are free for download. Successful treatment of bullous pemphigoid with omalizumab. The clinical diagnosis of bp was confirmed by histologic findings showing a subepidermal blister containing eosinophils and direct immunofluorescence analysis showing a linear deposit of igg and c3 at the basement. The target is the protein bp180 also called type xvii collagen, or less frequently bp230 a plakin.
Pemphigoid diseases including bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear iga dermatosis, lichen planus pemphigoides, and antip200 pemphigoid are a subgroup of autoimmune bullous skin diseases characterized by an autoantibody response toward structural components of the hemidesmosome resulting in subepidermal. Bullous pemphigoid pictures, treatment, symptoms, prognosis. If you continue browsing the site, you agree to the use of cookies on this website. Bullous pemphigoid has many distinct clinical features such as. Pemphigus is an autoimmune disorder that causes blistering and raw sores on skin and mucous membranes. The immune system is designed to keep the body healthy by fighting off infection and harmful invaders. Nov 20, 2015 bullous pemphigoid bp is the commonest subtype of autoimmune blistering disease aibd, a rare but potentially fatal group of skin diseases. Mainly igg autoantibodies bind to components of the hemidesmosome adhesion intricate, the bp230 and bp180 antigens.
Bullous pemphigoid is a skin disorder characterized by large blisters. Advances in understanding and managing bullous pemphigoid. Autoimmune bullous lesions of skin linkedin slideshare. The disease can be fatal, particularly in patients who are debilitated. Bullous pemphigoid skin disorders msd manual consumer. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Bullous pemphigoid treatment guidelines treatment for. Vesicles and bullae are accumulations of fluid within or under the epidermis. Bullous pemphigoid is a rare skin condition that typically affects people in middle age and beyond. A tiny proportion of cases can be started by certain therapies, for instant. Autoimmune disorders occur when the immune system malfunctions and begins producing antibodies that attack normal body tissue. If untreated, it can persist for months or years, with periods of spontaneous remissions and exacerbations. Bullous pemphigoid bullous pemphigoid bp is a rare, chronic, autoimmune, subepidermal, blistering disease of the skin. Their roofs are relatively thick and so they tend to be tense and intact.
Diagnosis is by skin biopsy and immunofluorescence testing of skin and serum. Bullous pemphigoid normally appears very erratically with no factors which are clear causative to the beginning of this disease. The other body part that is affected of this skin problem is the mucous membranes or our mouths. In up to 20% of affected patients, bullae may be completely absent, and only excoria. The blisters are usually located on the arms, legs, or middle of the body. These proteins are critical in attaching the top layer of skin cells the epidermis to the underlying. The clinical diagnosis of bp was confirmed by histologic findings showing a subepidermal blister containing eosinophils and direct immunofluorescence analysis showing a linear deposit of igg and c3 at the basement membrane zone. The onset and course of bp depend on a variable interaction between predisposing and inducing factors. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from.
Bp usually affects the elderly and has an incidence of 12. They develop on areas of skin that often flex such as the lower abdomen, upper thighs or armpits. Bullous means blistering and pemphigoid comes from the greek word pemphix and means bubbles. Bullous pemphigoid is a subepidermal bullous disorder characterized by large, tense blisters on the skin. Damien jonas wilson, md bullous pemphigoid bp is a condition that affects the skin with an autoimmune etiology. Bullous pemphigoid bp is an acquired, autoimmune, bullous disease that is characterized by autoantibodies against the 230kda bullous pemphigoid antigen within basal keratinocytes and the 180kda type xvii collagen within the basement membrane zone bmz lying between the epidermis and dermis. Bullous pemphigoid is an uncommon blistering condition of the elderly, which often starts with itch and urticated and erythematous lesions. He explained how pemphigoid was different from pemphigus by location and look of the blisters. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis.
352 646 1001 47 872 744 210 1387 269 797 1271 1642 131 1049 1065 1103 1604 22 1451 451 468 948 892 1145 283 1016 725 1560 270 1529 28 778 735 291 372 1207 207 525 333 657 400 1078 1423 22 602 232 1194 1065 24 538 758